999国产精品999久久久久久,香港经典a毛片免费观看,国产av在线私拍,97se亚洲国产综合在线

當前位置:首頁  >  技術文章  >  CDK11需要一個關鍵的激活子SAP30BP來調(diào)節(jié)pre-mRNA剪接

CDK11需要一個關鍵的激活子SAP30BP來調(diào)節(jié)pre-mRNA剪接

更新時間:2024-12-28  |  點擊率:102

202312月,中國科學院分子細胞科學研究中心;中國科學院上海生物化學與細胞生物學研究所;中國科學院RNA科學與工程重點實驗室;武漢大學生命科學學院;太康生命與醫(yī)學科學中心;RNA研究所;湖北省細胞穩(wěn)態(tài)重點實驗室;中國科學院分析化學分離科學重點實驗室;武漢中國科學院大連化學物理研究所國家色譜研究中心;中國科學院大學杭州高等研究院生命科學學院浙江省系統(tǒng)健康科學重點實驗室(Key Laboratory of RNA Science and Engineering, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China;College of Life Sciences, TaiKang Center for Life and Medical Sciences, RNA Institute, Hubei Key Laboratory of Cell Homeostasis, Wuhan University, Wuhan, China;CAS Key Laboratory of Separation Sciences for Analytical Chemistry,  National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, ChinaKey Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences,Hangzhou, China) Jing Fan老師研究團隊在《The EMBO Journal》上發(fā)表論文:

CDK11 requires a critical activator SAP30BP to regulate pre-mRNA splicing"

 

CDK11需要一個關鍵的激活子SAP30BP來調(diào)節(jié)pre-mRNA剪接"

 

Abstract

CDK11 is an emerging druggable target for cancer therapy due to its prevalent roles in phosphorylating critical transcription and splicing factors and in facilitating cell cycle progression in cancer cells. Like other cyclin-dependent kinases, CDK11 requires its cognate cyclin, cyclin L1 or cyclin L2, for activation. However, little is known about how CDK11 activities might be modulated by other regulators. In this study, we show that CDK11 forms a tight complex with cyclins L1/L2 and SAP30BP, the latter of which is a poorly characterized factor. Acute degradation of SAP30BP mirrors that of CDK11 in causing widespread and strong defects in pre-mRNA splicing. Furthermore, we demonstrate that SAP30BP facilitates CDK11 kinase activities in vitro and in vivo, through ensuring the stabilities and the assembly of cyclins L1/L2 with CDK11. Together, these findings uncover SAP30BP as a critical CDK11 activator that regulates global pre-mRNA splicing.


摘要:

CDK11是一個新興的癌癥治療藥物靶點,因為它在磷酸化關鍵轉錄和剪接因子以及促進癌細胞細胞周期進程中發(fā)揮著普遍作用。像其他細胞周期蛋白依賴性激酶一樣,CDK11需要其同源細胞周期蛋白,細胞周期蛋白L1或細胞周期蛋白L2來激活。然而,對于CDK11的活性如何被其他調(diào)節(jié)因子調(diào)節(jié),研究人員所知甚少。在這項研究中,研究人員發(fā)現(xiàn)CDK11與細胞周期蛋白L1/L2SAP30BP形成緊密復合物,后者是一個特征不明顯的因子。SAP30BP的急性降解與CDK11一樣,在pre-mRNA剪接中引起廣泛而強烈的缺陷。此外,研究人員證明SAP30BP通過確保細胞周期蛋白L1/L2CDK11的穩(wěn)定性和組裝,促進了CDK11激酶在體外和體內(nèi)的活性。綜上所述,這些發(fā)現(xiàn)揭示了SAP30BP作為一個關鍵的CDK11激活因子,調(diào)控全局pre-mRNA剪接。

 

該論文中,HeLa HAP1細胞的體外培養(yǎng)是使用Ausbian特級胎牛血清完成的。


欧美牲交a欧美牲交aⅴ久久 | 人妻无码中文专区久久五月婷| 亚洲日韩乱码久久久久久| 亚洲精品无码久久久久APP| 莫妮卡欧美R级无删版影片| 国产男女猛烈无遮挡免费视频| 人人添人人妻人人爽夜欢视AV| 精品国产三级A∨在线欧美 | 国产性生交XXXXX免费| GOGO少妇无码肉肉视频| 少妇无码av无码专区线| 国产色综合久久无码有码| 中文在线无码高潮潮喷| 妻子6免费完整版电影| 秋霞国产成人精品午夜视频APP| 久久人人爽人人爽人人片Ⅴ | 最近中文字幕免费mv视频7| 亚洲色久悠悠av在线观看| 啊灬啊灬快灬高潮了视频| 国产精品h片在线播放| 成人国内精品久久久久影院| 亚洲精品成人无码中文毛片| 在线毛片片免费观看| 欧美丰满大胆少妇xxxooo| 免费看无码自慰一区二区| 久久精品国产精品国产精品污| GOGO少妇无码肉肉视频| 777国产偷窥盗摄精品品在线| 欧美激情无码视频一二三| 精品国产偷窥一区二区| 无码福利一区二区三区 | 中文字幕精品亚洲无线码二区| 在线播放亚洲第一字幕| 日本护士吞精囗交gif| 久久精品国产网红主播| 国产一区二区在线视频| 777国产偷窥盗摄精品品在线 | 精品熟女少妇av免费久久| 熟女少妇在线视频播放| 小蜜被两老头吸奶头在线观看| 久久久久国产精品|